| Official Full Name |
Recombinant Murine Interleukin-36 Receptor Antagonist Protein (rMuIL-36RA) |
| Squence |
 |
| Amino Acid Sequence |
VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD |
| Synonyms |
IL-1HY1, IL-1 delta, IL-1F5, IL-1H3, IL-1L1 |
| Accession Number |
Q9QYY1 |
| GeneID |
54450 |
| Summary |
|
| Source |
Escherichia coli. |
| Molecular Weight |
Approximately 16.9 kDa, a single non-glycosylated polypeptide chain containing 154 amino acids. |
| Biological Activity |
Measured by its ability to inhibit IL-36gamma induced IL-6 production by human PBMCs. |
| Appearance |
Sterile filtered white lyophilized (freeze-dried) powder. |
| Formulation |
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4. |
| Endotoxin |
Less than 1 EU/ug of rMuIL-36RA as determined by LAL method. |
| Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution. |
| References |
1. Born TL, Smith DE, Garka KE, et al. 2000. J Biol Chem. 275:41528.2. Dunn EF, Gay NJ, Bristow AF, et al. 2003. Biochemistry. 42:10938-44.3. Barton JL, Herbst R, Bosisio D, et al. 2000. Eur J Immunol. 30:3299-308.4. Debets R, Timans JC, Homey B, et al. 2001. J Immunol. 167:1440-6.5. Towne JE, Renshaw BR, Douangpanya J, et al. 2011. J Biol Chem. 286:42594-602. |
| SDS-PAGE |
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| Safety Data Sheet (SDS) Download |
Click to download |
| Technical Data Sheet (TDS) Download |
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