ABC-type xenobiotic transporter EC#: 7.6.2.2

Product Name ABC-type xenobiotic transporter
Example Structure Example Structure of ABC-type xenobiotic transporter EC#: 7.6.2.2
Synonyms ABC drug transporter, ABC multidrug efflux transporter, ABCB1, Abcb1a, ABCC1, ABCC10, ABCC2, ABCC3, ABCC4, ABCG2, AcrB, acriflavine resistance protein, ATP phosphohydrolase (xenobiotic-exporting), ATP-binding cassette drug transporter, ATP-binding cassette G subfamily member 2, ATP-binding cassette transporter, BCRP, Bcrp1, bile transporter, Bmr, BmrA, breast cancer resistance protein, canalicular multispecific organic anion transporter, Candida drug resistance 1 protein, CDR1, Cdr1p, cMOAT, DMRP, DrrAB, EcdL, EfrAB, EfrCD, EfrEE, Ha-Pgp, hmr19 gene product, LmrA, MdfA, MDR, MDR transporter, MDR-ABC transporter, MDR1, MDR1 P-glycoprotein, Mdr1a, MDR1b, Mdr2, Mdr3, MDR3 P-glycoprotein, MDR4, MDR5, MDR6, MDR7, MOAT, More, MRD1a, MRP, MRP1, MRP1/ABCC1, MRP2, MRP3, MRP3/ABCC3, MRP4, MRP5, MRP7, multidrug ABC transporter, multidrug ATP-binding cassette transporter, multidrug efflux transporter, multidrug resistance ABC transporter, multidrug resistance associated protein 5, multidrug resistance gp170, multidrug resistance protein, multidrug resistance protein 1, multidrug resistance protein 2, multidrug resistance protein 3, multidrug resistance protein 4, multidrug resistance protein 7, multidrug resistance transporter, multidrug resistance transporter 1, multidrug resistance-associated protein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, multidrug resistance-associated protein 4, multidrug resistance-associated protein 5, multidrug resistance-associated protein 7, multidrug resistance-linked ATP-binding cassette transporter, multidrug resistanceassociated protein 1, multidrug resistant transporter, multidrug transporter, multidrug-resistance protein, multidrugresistance 1, P-glycoprotein, P-glycoprotein multidrug efflux pump, P-glycoprotein-ATPase, P-gp, P-gp ABC transporter, PatA/PatB, Pdr18, PDR5, Pdr5p, Pgh1, Pgp, PGP1, Pgp2, PGY1, phosphatidylcholine translocator, phospho-glycoprotein, Sav1866, Sav1886, SMDR2, Smr1, Snq2p, transporter protein MRP, xenobiotic ABC efflux transporter, xenobiotic-transporting ATPase, YdaG/YdbA, YvcC
EC Number 7.6.2.2
CAS Registry Number
Comments An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them also transport glutathione¡ªdrug conjugates (see EC?7.6.2.3, ABC-type glutathione-S-conjugate transporter) while others also show some ‘flippase’ activity (cf. EC?7.6.2.1, P-type phospholipid transporter).
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