acetate CoA-transferase EC#: 2.8.3.8; ChemWhat Code: 1379137
| Product Name | acetate CoA-transferase |
| Example Structure |  |
| Synonyms | AarC, acetate coenzyme A-transferase, acetate:succinate CoA-transferase, acetoacetate:acetate CoA-transferase, ActA, ASCT, But, butyryl CoA:acetate CoA transferase, butyryl coenzyme A transferase, butyryl coenzyme A:acetate transferase, butyryl-CoA: acetate CoA-transferase, butyryl-CoA:acetate CoA-transferase, butyryl-coenzyme A CoA transferase, coenzyme A-transferase, acetate, SCACT, succinyl-CoA:acetate CoA transferase, succinyl-CoA:acetate CoA-transferase, succinyl-coenzyme A:acetate CoA-transferase |
| EC Number | 2.8.3.8 |
| CAS Registry Number | 37278-35-6 |
| Comments | The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC?2.8.3.9, butyrate¡ªacetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA. |
| Cofactor | |
| History | |
| Reactions | Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. |
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