acyl-CoA 11-(Z)-desaturase EC#: 1.14.19.5; ChemWhat Code: 1375766
| Product Name | acyl-CoA 11-(Z)-desaturase |
| Example Structure |  |
| Synonyms | (Z)-11 myristoyl CoA desaturase, acyl-CoA DELTA11-desaturase, acyl-CoA desaturase, acyl-CoA Z/E11 desaturase, APTQ desaturase, bifunctional DELTA11-desaturase, bifunctional Z-DELTA11-desaturase, Cro-Z/E11, CroDELTA11 desaturase, DELTA11 desaturase, DELTA11-(Z)-desaturase, DELTA11-desaturase, DELTA11-fatty-acid desaturase, DELTA11-myristoyl-CoA desaturase, DELTA11-palmitoyl-CoA-desaturase, DELTA11-palmitoyl-coenzyme A desaturase, desat1, desaturase, myristoly coenzyme A (E)-11, Dpu-DELTA11-APSQ, Dpu-DELTA11-LPAE, fatty acid DELTA11-desaturase, fatty acyl DELTA11-desaturase, LATPG1, Lca-KPVQ, MambrD11-desaturase, More, myristoyl-CoA 11-(Z) desaturase, OfuZ/E11 protein, OscZ/E11 protein, PDesat-TnDELTA11 Z protein, Sls//E11, sphingolipid long chain base delta 8 desaturase, TpDESN, Z/E11-desaturase, Z/EDELTA11 |
| EC Number | 1.14.19.5 |
| CAS Registry Number | |
| Comments | The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. In moths the enzyme participates in the biosynthesis of their sex pheromones. The enzyme from the marine microalga Thalassiosira pseudonana is specific for palmitoyl-CoA (16:0) [4], that from the leafroller moth Choristoneura rosaceana desaturates myristoyl-CoA (14:0) [5], while that from the moth Spodoptera littoralis accepts both substrates [1]. The enzyme contains three histidine boxes that are conserved in all desaturases [2]. It is membrane-bound, and contains a cytochrome b5-like domain at the N-terminus that serves as the electron donor for the active site of the desaturase. |
| Cofactor | |
| History | |
| Reactions | An acyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = an (11Z)-enoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O. |
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