acyl-CoA (8-3)-desaturase EC#: 1.14.19.44; ChemWhat Code: 1375809

Product Name acyl-CoA (8-3)-desaturase
Example Structure Example Structure of acyl-CoA (8-3)-desaturase EC#: 1.14.19.44
Synonyms acyl-CoA 5-desaturase, acyl-CoA 5-desaturase (methylene-interrupted), D5D, DELTA 5-desaturase, delta-5 desaturase, DELTA5-desaturase, FADDELTA5, FADS1
EC Number 1.14.19.44
CAS Registry Number
Comments The enzyme introduces a cis double bond at carbon 5 of acyl-CoAs that contain a double bond at position 8. The enzymes from algae, mosses, mammals and the protozoan Leishmania major catalyse the desaturation of dihomo-¦Ã-linoleate ((8Z,11Z,14Z)-icosa-8,11,14-trienoate) and (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoate to generate arachidonate and (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate, respectively. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site and does not require an external cytochrome. cf. EC 1.14.19.37 acyl-CoA 5-desaturase.
Cofactor
History
Reactions (1) (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = arachidonoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O. (2) (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl- CoA + 2 ferricytochrome b5 + 2 H(2)O.

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