acyl-lipid omega-3 desaturase (cytochrome b5) EC#: 1.14.19.25; ChemWhat Code: 1375790
| Product Name | acyl-lipid omega-3 desaturase (cytochrome b5) |
| Example Structure |  |
| Synonyms | BjFad3, DELTA15 desaturase, endoplasmic reticulum-type omega-3 fatty acid desaturase, ER-localized omega-3 FA desaturase, ER-type desaturase, ER-type omega-3 fatty acid desaturase, FAD3, FAD3-1, FAD3-2, FAD3A, FAD3B, FAD3C, fatty acid desaturase 3, LeFAD3, maw3, msdd17, omefa3-desaturase, omega-3 desaturase, omega-3 FA desaturase, omega-3 FAD, omega-3 fatty acid desaturase, PfrFAD3, sdd17 |
| EC Number | 1.14.19.25 |
| CAS Registry Number | |
| Comments | This microsomal enzyme introduces a cis double bond three carbons away from the methyl end of a fatty acid incorporated into a glycerolipid. The distance from the carboxylic acid end of the molecule does not have an effect. The plant enzyme acts on carbon 15 of linoleoyl groups incorporated into both the sn-1 and sn-2 positions of the glycerol backbone of phosphatidylcholine and other phospholipids, converting them into ¦Á-linolenoyl groups. The enzyme from the fungus Mortierella alpina acts on ¦Ã-linolenoyl and arachidonoyl groups, converting them into stearidonoyl and icosapentaenoyl groups, respectively [3]. cf. EC 1.14.19.35, acyl-lipid ¦Ø?3 desaturase (ferredoxin). |
| Cofactor | |
| History | |
| Reactions | A linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = an alpha-linolenoyl-[glycerolipid] + ferricytochrome b5 + 2 H(2)O. |
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