acyl-lipid omega-6 desaturase (cytochrome b5) EC#: 1.14.19.22; ChemWhat Code: 1375787
| Product Name | acyl-lipid omega-6 desaturase (cytochrome b5) |
| Example Structure |  |
| Synonyms | 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine DELTA12-desaturase, 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine DELTAl2-desaturase, 18:1-phosphatidylcholine desaturase, acyl-lipid DELTA12-desaturase, BrFAD2-1, CeFAT-2, CtFAD2-1, delta 12 fatty acid desaturase, delta-12 fatty acid desaturase 2, Delta-12 oleate desaturase, delta-twelve fatty acid desaturase 2, DELTA12 desaturase, DELTA12-desaturase, DELTA12-fatty acid desaturase, DELTA12-oleoyl-phosphatidylcholine desaturase, desaturase, oleate, DiFAD2, endoplasmic reticulum-localized oleate desaturase, FAD2, FAD2-1, FAD2-1A, FAD2-1B, FAD2-2, FAD2-3, FAD2-4, FAD2A, FAD6, linoleate synthase, LKFAD15, microsomal oleate desaturase, microsomal oleic acid desaturase, microsomal omega-6 fatty acid desaturase, oleate desaturase, oleoyl phosphatidylcholine desaturase, oleoyl-CoA desaturase, oleoyl-PC desaturase, oleoyl-phosphatidylcholine desaturase, oleoylphosphatidylcholine desaturase, omega-6 desaturase, omega-6 fatty acid desaturase, omega-6-oleate desaturase, omega6-fatty acid desaturase, OsFAD2, plastidial oleate desaturase, seed-specific delta-12 fatty acid desaturase 2, SVE1, TauDELTA12des |
| EC Number | 1.14.19.22 |
| CAS Registry Number | 59929-36-1 |
| Comments | This microsomal enzyme introduces a cis double bond in fatty acids attached to lipid molecules at a location 6 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. The most common substrates are oleoyl groups attached to either sn-1 or sn-2 position of the glycerol backbone in phosphatidylcholine. cf. EC 1.14.19.23, acyl-lipid ¦Ø?6 desaturase (ferredoxin). |
| Cofactor | |
| History | |
| Reactions | An oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. |
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