ADAM 17 endopeptidase EC#: 3.4.24.86; ChemWhat Code: 1381099
| Product Name | ADAM 17 endopeptidase |
| Example Structure |  |
| Synonyms | (TACE/ADAM17/CD156q), (TACE:ADAM17), a disintegrin and metalloprotease 17, ADAM-17, ADAM17, ADAM17 proteinase, ADAM17/tumor necrosis factor-alpha (TNF-A)converting enzyme, ADAMTS-2, CD156, H-TACE, human TACE B, metalloprotease TACE, metalloprotease-disintegrin tumour necrosis factor alpha convertase, metalloproteinase ADAM17, pro tumor necrosis factor cleavage enzyme, pro-tumor necrosis factor-alpha-processing enzyme, proteinase, pro-tumor necrosis factor (9CI), sheddase, TACE, TACE proteinase, TACE/ADAM17, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha processing protease, tumor necrosis factor alpha convertase, tumor necrosis factor alpha converting enzyme, tumor necrosis factor alpha-converting enzyme, tumor necrosis factor-alpha converting enzyme, tumor necrosis factor-alpha-converting enzyme, tumour necrosis factor alpha-converting enzyme |
| EC Number | 3.4.24.86 |
| CAS Registry Number | |
| Comments | In peptidase family?M12. In vivo, the cleavage of tumor necrosis factor ¦Á precursor releases the soluble, 17-kDa TNF¦Á, which induces inflammation. |
| Cofactor | Zn2+ |
| History | |
| Reactions | Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to ‘shed’ the extracellular domains. |
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