Adamalysin II, Crotalus adamanteus metalloendopeptidase, Crotalus adamanteus venom proteinase II, metargidin, Proteinase I and II, Proteinase, Crotalus adamanteus venom, II
EC Number
3.4.24.46
CAS Registry Number
74812-51-4
Comments
From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate ¦Á1-proteinase inhibitor by a single cleavage. In peptidase family?M12?(astacin family).
Cofactor
Zn2+
History
Reactions
Cleavage of 1-Phe-|-Val-2, 5-His-|-Leu-6, 14-Ala-|-Leu-15, 15-Leu-|-Tyr- 16, and 16-Tyr-|-Leu-17 of insulin B chain.
