adenosyl-chloride synthase EC#: 2.5.1.94; ChemWhat Code: 1378028

Product Name adenosyl-chloride synthase
Example Structure Example Structure of adenosyl-chloride synthase EC#: 2.5.1.94
Synonyms 5′-chloro-5′-deoxyadenosine synthase, AclH, chlorinase, S-adenosyl-L-methionine-dependent chlorinase, SalL, SAM-dependent chlorinase
EC Number 2.5.1.94
CAS Registry Number
Comments This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride.
Cofactor
History
Reactions S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine.J3803

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