alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase EC#: 2.4.1.145; ChemWhat Code: 1377435
| Product Name | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
| Example Structure |  |
| Synonyms | (GnT)-IVa, (GnT)-IVb, alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase, alpha1,3-mannosyl-beta1,4-N-acetylglucosaminyltransferase IV, beta-acetylglucosaminyltransferase IV, GlcNAcTase-IV, GnT IV, GnT-IVa, GnT-IVb, GnTIVa, Mgat4a, Mgat4b, N-acetylglucosaminyltransferase IV, N-acetylglucosaminyltransferase IVa, N-acetylglucosaminyltransferase-IV, N-acetylglucosaminyltransferase-IVa, N-acetylglucosaminyltransferase-IVb, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV |
| EC Number | 2.4.1.145 |
| CAS Registry Number | 86498-16-0 |
| Comments | Requires Mn2+. The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus. By adding a glucosaminyl residue to biantennary N-linked glycans, it enables the synthesis of tri- and tetra-antennary complexes. Formerly EC 2.4.1.51. |
| Cofactor | |
| History | |
| Reactions | UDP-N-acetyl-D-glucosamine + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D- mannosyl)-beta-D-mannosyl-R = Udp + 3-(2,4-bis(N-acetyl-beta-D- glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R. |
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