| Product Name |
alpha-bisabolene synthase |
| Example Structure |
 |
| Synonyms |
(E)-alpha-bisabolene synthase, apha-bisabolene synthase, beta-bisabolene synthase, BIS, bisabolene synthase, E-alpha-bisabolene synthase, GbTPS2, More, TPS2, TPS3 |
| EC Number |
4.2.3.38 |
| CAS Registry Number |
|
| Comments |
This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+?or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC?4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir?Abies grandis?as a response to stem wounding. |
| Cofactor |
Mg2+ |
| History |
|
| Reactions |
(2E,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate. |
