| Product Name |
alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase |
| Example Structure |
 |
| Synonyms |
P279_10500, phnJ |
| EC Number |
4.7.1.1 |
| CAS Registry Number |
|
| Comments |
This radical SAM (AdoMet) enzyme is part of the C-P lyase complex, which is responsible for processing phophonates into usable phosphate. Contains an [4Fe-4S] cluster. The enzyme from the bacterium?Escherichia coli?can act on additional ¦Á-D-ribose phosphonate substrates with different substituents attached to the phosphonate phosphorus (e.g. ¦Á-D-ribose-1-[N-(phosphonomethyl)glycine]-5-phosphate and ¦Á-D-ribose-1-(2-N-acetamidomethylphosphonate)-5-phosphate). |
| Cofactor |
S-adenosyl-L-methionine
iron-sulfur |
| History |
|
| Reactions |
Alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine + reduced electron acceptor = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane + L-methionine + 5′-deoxyadenosine + electron acceptor. |
