The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (+)-¦Á-santalene, (?)-¦Â-santalene and (?)-exo-¦Á-bergamotene are formed with traces of (+)-epi-¦Â-santalene. See EC?4.2.3.83?[(?)-¦Â-santalene synthase], and EC?4.2.3.81?[(?)-exo-¦Á-bergamotene synthase]. cf. EC?4.2.3.50?¦Á-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing].