alpha,alpha-trehalose synthase EC#: 2.4.1.245; ChemWhat Code: 1377554
| Product Name | alpha,alpha-trehalose synthase |
| Example Structure |  |
| Synonyms | PH1035, TmTreT, trehalose glycosyltransferring synthase, Trehalose synthase, TreT |
| EC Number | 2.4.1.245 |
| CAS Registry Number | |
| Comments | Requires Mg2+ for maximal activity [1]. The enzyme-catalysed reaction is reversible [1]. In the reverse direction to that shown above, the enzyme is specific for ¦Á,¦Á-trehalose as substrate, as it cannot use ¦Á- or ¦Â-paranitrophenyl glucosides, maltose, sucrose, lactose or cellobiose [1]. While the enzymes from the thermophilic bacterium Rubrobacter xylanophilus and the hyperthermophilic archaeon Pyrococcus horikoshii can use ADP-, UDP- and GDP-¦Á-D-glucose to the same extent [2,3], that from the hyperthermophilic archaeon Thermococcus litoralis has a marked preference for ADP-¦Á-D-glucose [1] and that from the hyperthermophilic archaeon Thermoproteus tenax has a marked preference for UDP-¦Á-D-glucose [4]. |
| Cofactor | Mg2+ |
| History | |
| Reactions | NDP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + Ndp. |
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