anaerobilin synthase EC#: 2.1.1.342; ChemWhat Code: 1376628
| Product Name | anaerobilin synthase |
| Example Structure |  |
| Synonyms | chuW |
| EC Number | 2.1.1.342 |
| CAS Registry Number | |
| Comments | The enzyme, studied from the bacterium Escherichia coli O157:H7, is a radical SAM (AdoMet) enzyme that is involved in heme degradation and iron utilization under anaerobic conditions. The enzyme uses two SAM molecules for the reaction. The first molecule is used to generate a 5′-deoxyadenosyl radical, which abstracts a hydrogen atom from the methyl group of the second SAM molecule. The newly formed methylene radical attacks the substrate, causing a rearrangement of the porphyrin ring that results in the liberation of iron. |
| Cofactor | |
| History | |
| Reactions | 2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5′-deoxyadenosine + anaerobilin + Fe(2+) + 2 oxidized flavodoxin. |
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