anthraniloyl-CoA anthraniloyltransferase EC#: 2.3.1.262; ChemWhat Code: 1377098
| Product Name | anthraniloyl-CoA anthraniloyltransferase |
| Example Structure |  |
| Synonyms | PqsD |
| EC Number | 2.3.1.262 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the synthesis of the secondary metabolites 2-heptyl-3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone. The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to an internal L-cysteine residue, followed by its transfer to malonyl-CoA to produce a short-lived product that can cyclize spontaneously to form 4-hydroxy-2(1H)-quinolone. However, when EC 3.1.2.32, 2-aminobenzoylacetyl-CoA thioesterase, is present, it removes the CoA moiety from the product, forming the stable 2-aminobenzoylacetate. |
| Cofactor | |
| History | |
| Reactions | Anthraniloyl-CoA + malonyl-CoA = 2-aminobenzoylacetyl-CoA + CoA + CO(2). |
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