| Synonyms |
4-methylumbelliferyl sulfatase, ARS, ARS-A, ARS-B, ARSA, ARSB, ARSE, ARSK, ary 423, Aryl-sulfate sulphohydrolase, arylsufatase B, arylsulfatase, arylsulfatase A, arylsulfatase B, arylsulfatase E, arylsulfatase Es-2, arylsulfatase G, arylsulfatase gene, arylsulfatase III, arylsulfatase J, arylsulfatase K, arylsulfatase type VI, arylsulfate sulfohydrolase II, arylsulfohydrolase, arylsulphatase, arylsulphatase A, AS-A, ASG, AstA, AtsA, estrogen sulfatase, KIAA1001, nitrocatechol sulfatase, p-nitrophenyl sulfatase, P70, PAS, phenolsulfatase, phenylsulfatase, sulfatase, sulfatase, aryl- |
| Comments |
Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-¦Â-lactamase fold and binds two zinc ions as cofactors. Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities. The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate. This residue is generated by posttranslational modification of a conserved cysteine or serine residue by EC?1.8.3.7, EC?1.1.98.-, serine-type anaerobic sulfatase-maturating enzyme, or EC?1.8.98.-, cysteine-type anaerobic sulfatase-maturating enzyme. |
