atrolysin C EC#: 3.4.24.42; ChemWhat Code: 1381029
Product Name
atrolysin C
Example Structure
Synonyms
aggrecanase, atrolysin, Crotalus atrox metalloendopeptidase c, hemorrhagic metalloproteinase HT-d, Hemorrhagic toxin c and d, PI metalloproteinase, Ruberlysin
EC Number
3.4.24.42
CAS Registry Number
158886-17-0
Comments
A 24 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests type IV collagen, and exists as two forms, c and d. Phosphoramidon inhibits in the 0.1 mM range. In peptidase family?M12?(astacin family). Hemorrhagic toxin-2 of?C. ruber ruber?has the same?Mr and specificity and is a homologue [4,6].
Cofactor
Zn2+
History
Reactions
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 of insulin B chain. With small molecule substrates prefers hydrophobic residue at P2′ and small residue such as Ala, Gly at P1.
