atrolysin E EC#: 3.4.24.44; ChemWhat Code: 1381032

Product Name atrolysin E
Example Structure Example Structure of atrolysin E EC#: 3.4.24.44
Synonyms atrolysin E/D, Crotalus atrox metalloendopeptidase e, Hemorrhagic toxin e, HT-e
EC Number 3.4.24.44
CAS Registry Number 172306-51-3
Comments A 25.7 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests basement membrane components, including the triple helix of type IV collagen. Such action is believed to contribute to the hemorrhagic property by weakening capillary walls. In peptidase family?M12?(astacin family).
Cofactor Zn2+
History
Reactions Cleavage of 3-Asn-|-Gln-4, 9-Ser-|-His-10 and 14-Ala-|-Leu-15 bonds in insulin B chain and 14-Tyr-|-Gln-15 and 8-Thr-|-Ser-9 in a chain. Cleaves type Iv collagen at 73-Ala-|-Gln-74 in alpha-1-(IV) and at 7-Gly-|-Leu-8 in alpha-2-(IV).

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