barbiturase EC#: 3.5.2.1; ChemWhat Code: 1381350
| Product Name | barbiturase |
| Example Structure |  |
| Synonyms | |
| EC Number | 3.5.2.1 |
| CAS Registry Number | 9025-16-5 |
| Comments | Contains zinc and is specific for barbiturate as substrate [3]. Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC?1.17.99.4?(uracil/thymine dehydrogenase) and EC?3.5.1.95?(N-malonylurea hydrolase). It was previously thought that the end-products of the reaction were malonate and urea but this has since been disproved [2]. May be involved in the regulation of pyrimidine metabolism, along with EC?2.4.2.9, uracil phosphoribosyltransferase. |
| Cofactor | Zn2+ |
| History | |
| Reactions | Barbiturate + H(2)O = 3-oxo-3-ureidopropanoate. |
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