caldopentamine synthase EC#: 2.5.1.127; ChemWhat Code: 1378071
| Product Name | caldopentamine synthase |
| Example Structure |  |
| Synonyms | HbSpe II, long-chain polyamine synthase |
| EC Number | 2.5.1.127 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from the thermophilic archaeon Hyperthermus butylicus, can also synthesize norspermine from norspermidine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.23, sym-norspermidine synthase and EC 2.5.1.126, norspermine synthase, this enzyme shows no activity with propane-1,3-diamine. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl 3-(methylthio)propylamine + norspermine = S-methyl- 5′-thioadenosine + caldopentamine. |
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