calpain-3 EC#: 3.4.22.54; ChemWhat Code: 1380781
| Product Name | calpain-3 |
| Example Structure |  |
| Synonyms | C3DIV, calcium-activated neutral proteinase 3, Calp3, calpain 3, calpain 3 (p94), calpain 3 domain IV, calpain 3/p94, calpain L3, calpain M, calpain p94, calpain-3, calpain3, CANP 3, CAPN3, Cn94, MP78, Mp84, muscle calpain, muscle-specific calcium-activated neutral protease 3, muscle-specific calpain, nCL-1, p94, p94-calpain, p94/calpain 3, skeletal muscle-specific calpain |
| EC Number | 3.4.22.54 |
| CAS Registry Number | |
| Comments | This Ca2+-dependent enzyme is found in skeletal muscle and is genetically linked to limb girdle muscular dystrophy type 2A [1,4]. The enzyme is activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site [4]. Substrates include the protein itself [3,4] and connectin/titin [2,5]. Belongs in peptidase family?C2. |
| Cofactor | Ca2+ |
| History | |
| Reactions | Broad endopeptidase activity. |
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