| Product Name |
carbazole 1,9a-dioxygenase |
| Example Structure |
 |
| Synonyms |
CarAa, CarAc, carbazole dioxygenase, CARDO, CARDO-F, CARDO-R |
| EC Number |
1.14.12.22 |
| CAS Registry Number |
|
| Comments |
This enzyme catalyses the first reaction in the pathway of carbazole degradation. The enzyme attacks at the 1 and 9a positions of carbazole, resulting in the formation of a highly unstable hemiaminal intermediate that undergoes a spontaneous cleavage and rearomatization, resulting in 2′-aminobiphenyl-2,3-diol. In most bacteria the enzyme is a complex composed of a terminal oxygenase, a ferredoxin, and a ferredoxin reductase. The terminal oxygenase component contains a nonheme iron centre and a Rieske [2Fe-2S] iron-sulfur cluster. |
| Cofactor |
iron-sulfur;Fe cation |
| History |
|
| Reactions |
9H-carbazole + NAD(P)H + O(2) = 2′-aminobiphenyl-2,3-diol + NAD(P)(+). |
