carboxylate reductase (NADP+) EC#: 1.2.1.30; ChemWhat Code: 1373775
| Product Name | carboxylate reductase (NADP+) |
| Example Structure |  |
| Synonyms | aromatic acid reductase, aryl-aldehyde dehydrogenase (NADP+) |
| EC Number | 1.2.1.30 |
| CAS Registry Number | 9074-94-6 |
| Comments | The enzyme contains an adenylation domain, a phosphopantetheinyl binding domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the phosphopantetheinyl binding domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to an aldehyde and released. |
| Cofactor | |
| History | |
| Reactions | An aromatic aldehyde + NADP(+) + Amp + diphosphate + H(2)O = an aromatic acid + Nadph + atp. |
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