caspase-11 EC#: 3.4.22.64; ChemWhat Code: 1380802
| Product Name | caspase-11 |
| Example Structure |  |
| Synonyms | C14.012, caspase 11, caspase-11, caspase-4, Ich-3, ICH-3 protease |
| EC Number | 3.4.22.64 |
| CAS Registry Number | |
| Comments | This murine enzyme is part of the family of inflammatory-caspases, which also includes caspase-1 (EC?3.4.22.36), caspase-4 (EC?3.4.22.57) and caspase-5 (EC?3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide [1]. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1¦Â (IL-1¦Â) and IL-18, but it also activates caspase-3 (EC?3.4.22.56), which leads to cellular apoptosis under pathological conditions [1,2]. Belongs in peptidase family?C14. |
| Cofactor | |
| History | |
| Reactions | Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-|- |
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