| Synonyms |
apoptotic protease Mch-3, C14.004, Casp7, caspase 7, caspase-7, CMH-1, cystein aspartic-specific protease-7, DEVDase, ICE-LAP3, ICE-like apoptotic protease 3, LICE2 cysteine protease, More, SCA-2, SREBP cleavage activity 2 |
| Comments |
Caspase-7 is an effector/executioner caspase, as are caspase-3 (EC?3.4.22.56) and caspase-6 (EC?3.4.22.59) [1]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides, [e.g. poly(ADP-ribose) polymerase (PARP)], which lead to the apoptotic phenotype [2]. Although a hydrophobic residue at P5 of caspase-2 (EC?3.4.22.55) and caspase-3 leads to more efficient hydrolysis, the amino-acid residue at this location in caspase-7 has no effect [3]. Caspase-7 is activated by the initiator caspases [caspase-8 (EC?3.4.22.61), caspase-9 (EC?3.4.22.62) and caspase-10 (EC?3.4.22.63)]. Removal of the N-terminal prodomain occurs before cleavage in the linker region between the large and small subunits [4]. Belongs in peptidase family?C14. |
