cholestanetriol 26-monooxygenase EC#: 1.14.15.15; ChemWhat Code: 1375703

Product Name cholestanetriol 26-monooxygenase
Example Structure Example Structure of cholestanetriol 26-monooxygenase EC#: 1.14.15.15
Synonyms 5beta-cholestane-3 alpha,7alpha,12alpha,26-tetrol dehydrogenase, 5beta-cholestane-3 alpha,7alpha,12alpha-triol-26-al oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, cholestanetriol 27-hydroxylase, cholesterol C-26 hydroxylase, cholesterol hydroxylase, CYP125A4, CYP27, CYP27A, CYP27A1, cytochrome P-450 sterol 26-hydroxylase, cytochrome P-450A, cytochrome P450 125A4, cytochrome P450 27A, cytochrome P450c27, dehydrogenase, cholestanetetrol 26-, hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol, More, oxygenase, cholestanetriol 26-mono-, P450 27A1, sterol 27-hydroxylase, TEHC-NAD oxidoreductase, vitamin D3 25-hydroxylase
EC Number 1.14.15.15
CAS Registry Number 52227-77-7
Comments This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. It catalyses the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. Can also act on cholesterol, cholest-5-en-3¦Â,7¦Á-diol, 7¦Á-hydroxycholest-4-en-3-one, and 5¦Â-cholestane-3¦Á,7¦Á-diol. The enzyme can also hydroxylate cholesterol at positions 24 and 25. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase.
Cofactor heme-thiolate
History
Reactions 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + 6 reduced adrenodoxin + 6 H(+) + 3 O(2) = (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta- cholestan-26-oate + 6 oxidized adrenodoxin + 4 H(2)O.

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