cholesterol 24-hydroxylase EC#: 1.14.14.25; ChemWhat Code: 1375531
| Product Name | cholesterol 24-hydroxylase |
| Example Structure |  |
| Synonyms | 24S-hydroxylase, CH24H, cholesterol 24-hydroxylase, cholesterol 24-monooxygenase, cholesterol 24S hydroxylase, cholesterol 24S-hydroxylase, cholesterol hydroxylase, cholesterol-24S-hydroxylase, CYP46, CYP46A, CYP46A1, cytochrome P-450 46A1, cytochrome P450 46A1, cytochrome P450 cholesterol 24-hydroxylase |
| EC Number | 1.14.14.25 |
| CAS Registry Number | |
| Comments | A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood¡ªbrain barrier whereas cholesterol cannot [3]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH¡ªhemoprotein reductase [3]. |
| Cofactor | heme-thiolate |
| History | |
| Reactions | Cholesterol + [reduced NADPH–hemoprotein reductase] + O(2) = (24S)- cholest-5-ene-3-beta,24-diol + [oxidized NADPH–hemoprotein reductase] + H(2)O. |
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