cholesterol 7alpha-monooxygenase EC#: 1.14.14.23; ChemWhat Code: 1375527
| Product Name | cholesterol 7alpha-monooxygenase |
| Example Structure |  |
| Synonyms | 7alpha-hydroxylase, bile acid-synthetic enzyme, C7alphaOH, cholesterol 7 alpha-hydroxylase, cholesterol 7-alpha hydroxylase, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, cholesterol 7a-hydroxylase, cholesterol 7alpha hydroxylase, cholesterol 7alpha-hydroxylase, cholesterol-NADPH oxidoreductase, 7alpha-hydroxylating, CYP125A4, CYP7A, CYP7A1, Cyp7alpha1, CYPVII, cytochrome P450 125A4, hepatic cholesterol 7alpha-hydroxylase, More, oxygenase, cholesterol 7alpha-mono- |
| EC Number | 1.14.14.23 |
| CAS Registry Number | 9037-53-0 |
| Comments | A P-450 heme-thiolate liver protein that catalyses the first step in the biosynthesis of bile acids. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH¡ªhemoprotein reductase. |
| Cofactor | heme-thiolate |
| History | |
| Reactions | Cholesterol + [reduced NADPH–hemoprotein reductase] + O(2) = 7-alpha- hydroxycholesterol + [oxidized NADPH–hemoprotein reductase] + H(2)O. |
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