chondroitin AC lyase EC#: 4.2.2.5; ChemWhat Code: 1382500
| Product Name | chondroitin AC lyase |
| Example Structure |  |
| Synonyms | A-Chase, AC I lyase, c-ACI, c-ACII, ChnAC, chon-AC-lyase, ChonAC, chondroitin AC eliminase, chondroitin AC I lyase, Chondroitin AC lyase, chondroitin ACII lyase, chondroitin lyase AC, chondroitin sulfate lyase, chondroitinase, chondroitinase AC, chondroitinase ACI, chondroitinase ACII, ChSase-AC, EC 4.2.99.6, F-Chase, lyase, chondroitin AC, Pedsa_3808, PL8A |
| EC Number | 4.2.2.5 |
| CAS Registry Number | 9047-57-8 |
| Comments | Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and?N-acetylgalactosamine (GalNAc) [-4)GlcA(¦Â1-3)GalNAc(¦Â1-]n, which may be?O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(¦Á1-3)GalNAc(¦Â1-]n?of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [4]. |
| Cofactor | |
| History | |
| Reactions | Eliminative degradation of polysaccharides containing 1,4-beta-D- hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. |
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