classical-complement-pathway C3/C5 convertase EC#: 3.4.21.43; ChemWhat Code: 1380531
| Product Name | classical-complement-pathway C3/C5 convertase |
| Example Structure |  |
| Synonyms | C3 convertase, C3/C5 convertase, C3b 2 Bb, C3b2Bb, C3bBb, C3bBbP, C4, C423, C4b,2a, C4b,2a,3b, C4b,C2a, C4b2a, C4b2a3b, C4b2aC3b, C4bC2a, C5 convertase, classical C3 convertase, classical C5 convertase, classical pathway C3 convertase, classical pathway C3/C5 convertase, classical pathway C5 convertase, complement C3 convertase, CP C5 convertase, EAC1,C4b,C2a, high affinity C5 convertase, soluble C3 convertase, surface-bound C3 convertase |
| EC Number | 3.4.21.43 |
| CAS Registry Number | 56626-15-4 |
| Comments | A complex of complement fragments C4b, C2a and C2b. C2a contains the active site, C2b the site for C4b binding. C2a and C2b are formed by cleavage of proenzyme C2 by complement subcomponent C1?s?. Cleavage of C5 requires complement fragment C3b which binds C5 and renders it susceptible to cleavage by the C4b,2a complex. Includes former EC?3.4.21.44. Complement component C2a is in peptidase family?S1?(trypsin family). |
| Cofactor | |
| History | |
| Reactions | Selective cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b. |
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