clavaminate synthase EC#: 1.14.11.21; ChemWhat Code: 1375101
| Product Name | clavaminate synthase |
| Example Structure |  |
| Synonyms | CAS, CAS1, CAS2, clavaminate synthase 1, clavaminate synthase 2, clavaminic acid synthase, CS, synthase, clavaminate |
| EC Number | 1.14.11.21 |
| CAS Registry Number | |
| Comments | Contains nonheme iron. Catalyses three separate oxidative reactions in the pathway for the biosythesis of the ¦Â-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site. |
| Cofactor | Fe cation |
| History | |
| Reactions | (1) Deoxyamidinoproclavaminate + 2-oxoglutarate + O(2) = amidinoproclavaminate + succinate + CO(2). (2) Proclavaminate + 2-oxoglutarate + O(2) = dihydroclavaminate + succinate + CO(2) + H(2)O. (3) Dihydroclavaminate + 2-oxoglutarate + O(2) = clavaminate + succinate + CO(2) + H(2)O. |
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