CMP-N-acetylneuraminate monooxygenase EC#: 1.14.18.2; ChemWhat Code: 1375749
| Product Name | CMP-N-acetylneuraminate monooxygenase |
| Example Structure |  |
| Synonyms | CMAH, CMP Neu5Ac hydroxylase, CMP-N-acetylneuraminate hydroxylase, CMP-N-acetylneuraminate,NAD(P)H:oxygen oxidoreductase (hydroxylating), CMP-N-acetylneuraminic acid hydroxylase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase, cytidine monophosphate-N-acetylneuraminic acid hydroxylase, cytidine monophospho-N-acetylneuraminic acid hydroxylase, EC 1.14.13.45, oxygenase, cytidine monophosphoacetylneuraminate mono-, pcmah |
| EC Number | 1.14.18.2 |
| CAS Registry Number | 116036-67-0 |
| Comments | This enzyme contains both a Rieske-type [2Fe-2S] cluster and a second iron site. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2). The enzyme can be activated by Fe2+ or Fe3+. |
| Cofactor | Fe cation;iron-sulfur |
| History | |
| Reactions | CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O(2) + 2 H(+) = CMP-N- glycoloylneuraminate + 2 ferricytochrome b5 + H(2)O. |
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