| Product Name |
cobalt-precorrin 5A hydrolase |
| Example Structure |
 |
| Synonyms |
CbiG |
| EC Number |
3.7.1.12 |
| CAS Registry Number |
|
| Comments |
This enzyme hydrolyses the ring A acetate ¦Ä-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde. This is a key reaction in the contraction of the porphyrin-type tetrapyrrole ring and its conversion to a corrin ring in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway. |
| Cofactor |
|
| History |
|
| Reactions |
Cobalt-precorrin-5A + H(2)O = cobalt-precorrin-5B + acetaldehyde + 2 H(+). |
