cullin-RING-type E3 NEDD8 transferase EC#: 2.3.2.32; ChemWhat Code: 1377194
| Product Name | cullin-RING-type E3 NEDD8 transferase |
| Example Structure |  |
| Synonyms | cullin 2-RBX1 E3 ligase, DCN-1, Dcn1, Dcn1p, DCUN1D1, HRT1, Nedd8 E3 ligase, RBX-1, RBX1, ROC1, SCCRO |
| EC Number | 2.3.2.32 |
| CAS Registry Number | |
| Comments | Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to bind a substrate protein directly. Instead, they form a complex with a cullin scaffold protein and a substrate recognition module, which is named CRL for Cullin-RING-Ligase. The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation. The transfer of NEDD8 from a NEDD8-specific E2 enzyme onto the cullin protein is a secondary function of the RING-type E3 ubiquitin transferase in the CRL complex. The process requires auxiliary factors that belong to the DCN1 (defective in cullin neddylation 1) family. |
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