curacin A enoyl-acyl carrier protein reductase EC#: 1.3.1.B14; ChemWhat Code: 1373958
| Product Name | curacin A enoyl-acyl carrier protein reductase |
| Example Structure |  |
| Synonyms | curacin enoyl reductase, CurK |
| EC Number | 1.3.1.B14 |
| CAS Registry Number | |
| Comments | Binds FMN, FAD and a [2Fe-2S] cluster. The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit [4]. The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. |
| Cofactor | iron-sulfur;FAD;FMN |
| History | preliminary BRENDA-supplied EC number |
| Reactions |
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