cyclic-guanylate-specific phosphodiesterase EC#: 3.1.4.52; ChemWhat Code: 1379629
| Product Name | cyclic-guanylate-specific phosphodiesterase |
| Example Structure |  |
| Synonyms | Arr, BB0374, BCG_1419c, Bd1817, BifA, BinA, Blrp, BlrP1, blue light-regulated phophodiesterase, BpdA, BpdB, c-di-GMP phosphodiesterase, c-di-GMP-hydrolyzing-phosphodiesterase, c-di-GMP-specific PDE, c-di-GMP-specific phosphodiesterase, CC3396, CD0757, CdgC, CdpA, cyclic di-GMP phosphodiesterase, cyclic di-GMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic-di-GMP phosphodiesterase, diguanylate cyclase/phosphodiesterase, Dos, EAL, EAL domain phosphodiesterase, FimX, GAF/HD-GYP protein, H-NOX-associated cyclic-di-GMP processing enzyme, HaCE, HD-GYP, HD-GYP domain cyclic di-GMP phosphodiesterases, HD-GYP domain cyclic dimeric GMP phosphodiesterase, HD-GYP domain cyclic-di-GMP phosphodiesterase, HD-GYP PDE, HD-GYP phosphodiesterase, MbaA, MtbDGC, MtbPDE, PA2567, PA3947, PA4108, PA4367, PA4781, PAS-GGDEF-EAL domain-containing protein, PDE, PDE-A, PdeA, PDEA1, PdeB, PdeC, PdeH, perma_0986, phosphodiesterase A, PmGH, Putative uncharacterized protein, RapA, RavR, RbdA, RocR, RpfG, RpfR, ScrG, SO0437, TM0186, TM_0186, VieA, YahA, YcgF, YfgF |
| EC Number | 3.1.4.52 |
| CAS Registry Number | 338732-46-0 |
| Comments | Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3′,5′-guanylate, the product of EC?2.7.7.65, diguanylate cyclase and an allosteric activator of EC?2.4.1.12, cellulose synthase (UDP-forming), rendering it inactive [1]. It is the balance between these two enzymes that determines the cellular level of c-di-GMP [1]. |
| Cofactor | Mn2+;heme;Mg2+ |
| History | |
| Reactions | Cyclic di-3′,5′-guanylate + H(2)O = 5′-phosphoguanylyl(3′->5′)guanosine. |
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