| Product Name |
cypemycin cysteine dehydrogenase (decarboxylating) |
| Example Structure |
 |
| Synonyms |
CYPD, cypemycin decarboxylase, cypemycin dehydratase. |
| EC Number |
1.3.99.36 |
| CAS Registry Number |
|
| Comments |
Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide. Formerly EC 1.3.99.n3. |
| Cofactor |
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| History |
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| Reactions |
Cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys + acceptor = C(3,19),S(21)- cypemycin(1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO(2) + H(2)S + reduced acceptor. |
