D-2-hydroxyacid dehydrogenase (NAD+) EC#: 1.1.1.345; ChemWhat Code: 1373462
| Product Name | D-2-hydroxyacid dehydrogenase (NAD+) |
| Example Structure |  |
| Synonyms | |
| EC Number | 1.1.1.345 |
| CAS Registry Number | |
| Comments | The enzymes, characterized from bacteria (Peptoclostridium difficile, Enterococcus faecalis and from lactic acid bacteria) prefer substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain. It also utilizes phenylpyruvate. The enzyme from the halophilic archaeon Haloferax mediterranei prefers substrates with a main chain of 3-4 carbons (pyruvate and 2-oxobutanoate). cf. EC 1.1.1.272, D-2-hydroxyacid dehydrogenase (NADP+). |
| Cofactor | |
| History | |
| Reactions | An (R)-2-hydroxcarboxylate + NAD(+) = a 2-oxocarboxylate + Nadh. |
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