D-alanine-(R)-lactate ligase EC#: 6.1.2.1; ChemWhat Code: 1383585
| Product Name | D-alanine-(R)-lactate ligase |
| Example Structure |  |
| Synonyms | D-Ala-D-Lac ligase, D-Ala:D-Lac ligase, D-alanine-D-lactate ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-alanine:D-lactate ligase, D-alanyl-D-lactate ligase, depsipeptide ligase, VanA, VanB, VanD, VanD4, VanI, VRSA-9 Ddl |
| EC Number | 6.1.2.1 |
| CAS Registry Number | |
| Comments | The product of this enzyme, the depsipeptide?D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual?D-alanyl-D-alanine dipeptide, which is formed by EC?6.3.2.4,?D-alanine¡ªD-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria. |
| Cofactor | |
| History | |
| Reactions | D-alanine + (R)-lactate + Atp = D-alanyl-(R)-lactate + adp + phosphate. |
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