| Product Name |
dCTP deaminase (dUMP-forming) |
| Example Structure |
 |
| Synonyms |
DCD-DUT, DCD:DUT, dcdB, DCDDUT, dCTP deaminase-dUTP pyrophosphatase, dCTP deaminase-dUTPase, MJ0430 |
| EC Number |
3.5.4.30 |
| CAS Registry Number |
|
| Comments |
Requires Mg2+. Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. While most bacteria require two enzymes to form dUMP from dCTP (EC?3.5.4.13, dCTP deaminase and EC?3.6.1.23, dUTP diphosphatase), the archaeon?Methanocaldococcus jannaschii?uses a single enzyme to carry out both functions. This enzyme can also act as a dUTP diphosphatase, but more slowly. |
| Cofactor |
Mg2+ |
| History |
|
| Reactions |
dCTP + 2 H(2)O = dUMP + diphosphate + NH(3). |
