demethylrebeccamycin-D-glucose O-methyltransferase EC#: 2.1.1.164; ChemWhat Code: 1376367

Product Name demethylrebeccamycin-D-glucose O-methyltransferase
Example Structure Example Structure of demethylrebeccamycin-D-glucose O-methyltransferase EC#: 2.1.1.164
Synonyms rebeccamycin MT, rebeccamycin O-methyltransferase, RebM, RebM.
EC Number 2.1.1.164
CAS Registry Number
Comments Catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers [1]. The enzyme is a member of the general acid/base-dependent O-methyltransferase family [2].
Cofactor
History
Reactions 4′-demethylrebeccamycin + S-adenosyl-L-methionine = rebeccamycin + S-adenosyl-L-homocysteine.

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