deoxyribonuclease IV EC#: 3.1.21.2; ChemWhat Code: 1379729
| Product Name | deoxyribonuclease IV |
| Example Structure |  |
| Synonyms | apurinic/apyrimidinic endonuclease, coliphage T4 endonuclease II, deoxriboendonuclease, DNA-adenine-transferase, E. coli endonuclease IV, EC 3.1.4.30, End, Endo IV, endodeoxyribonuclease IV, EndoII, EndoIV, endonuclease II, endonuclease IV, exonuclease III, More, MtbEndo IV, MtbNfo, MtbXthA, Nfo, nuclease, endodeoxyribo-oder redoxyendonuclease, Rv0670, Sco4631, ScoA3McrA, T4 endonuclease IV, TthNfo, type IV methyl-dependent restriction endonuclease |
| EC Number | 3.1.21.2 |
| CAS Registry Number | 37211-67-9 |
| Comments | The enzyme is an apurinic/apyrimidinic (AP) site endonuclease that primes DNA repair synthesis at AP sites. It specifically cleaves the DNA backbone at AP sites and also removes 3′ DNA-blocking groups such as 3′ phosphates, 3′ phosphoglycolates, and 3′ ¦Á,¦Â-unsaturated aldehydes that arise from oxidative base damage and the activity of combined glycosylase/lyase enzymes. It is also the only known repair enzyme that is able to cleave the DNA backbone 5′ of the oxidative lesion ¦Á-deoxyadenosine. The enzyme has a strong preference for single-stranded DNA. Formerly EC?3.1.4.30. |
| Cofactor | |
| History | |
| Reactions | Endonucleolytic cleavage to 5′-phosphooligonucleotide end-products. |
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