desampylase EC#: 3.4.19.15; ChemWhat Code: 1380440
| Product Name | desampylase |
| Example Structure |  |
| Synonyms | HvJAMM1, HVO_2505, JAMM1 |
| EC Number | 3.4.19.15 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from the archaeon?Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolysing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein. The enzyme contains Zn2+.?cf. EC?3.4.19.12, ubiquitinyl hydrolase 1. Belongs to peptidase family?M67. |
| Cofactor | Zn2+ |
| History | |
| Reactions | An N(6)-[small archaeal modifier protein]-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + a [small archaeal modifier protein]. |
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