diadenosine hexaphosphate hydrolase (AMP-forming) EC#: 3.6.1.60; ChemWhat Code: 1381629

Product Name diadenosine hexaphosphate hydrolase (AMP-forming)
Example Structure Example Structure of diadenosine hexaphosphate hydrolase (AMP-forming) EC#: 3.6.1.60
Synonyms DIPP, hAps1, hAps2, NUDT10, NUDT11
EC Number 3.6.1.60
CAS Registry Number
Comments A divalent cation is essential for activity. Mn2+?(2-6 mM) is most effective. The enzyme controls intracellular levels of?P1,P5-bis(5′-adenosyl)pentaphosphate and?P1,P6-bis(5′-adenosyl)hexaphosphate. Weak activity with?P1,P4-bis(5′-adenosyl)tetraphosphate. Marked preference for adenine over guanine nucleotides.
Cofactor
History
Reactions (1) P(1),P(6)-bis(5′-adenosyl)hexaphosphate + H(2)O = adenosine 5′-pentaphosphate + Amp. (2) P(1),P(5)-bis(5′-adenosyl)pentaphosphate + H(2)O = adenosine 5′-tetraphosphate + Amp.

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