| Product Name |
diadenosine hexaphosphate hydrolase (AMP-forming) |
| Example Structure |
 |
| Synonyms |
DIPP, hAps1, hAps2, NUDT10, NUDT11 |
| EC Number |
3.6.1.60 |
| CAS Registry Number |
|
| Comments |
A divalent cation is essential for activity. Mn2+?(2-6 mM) is most effective. The enzyme controls intracellular levels of?P1,P5-bis(5′-adenosyl)pentaphosphate and?P1,P6-bis(5′-adenosyl)hexaphosphate. Weak activity with?P1,P4-bis(5′-adenosyl)tetraphosphate. Marked preference for adenine over guanine nucleotides. |
| Cofactor |
|
| History |
|
| Reactions |
(1) P(1),P(6)-bis(5′-adenosyl)hexaphosphate + H(2)O = adenosine 5′-pentaphosphate + Amp. (2) P(1),P(5)-bis(5′-adenosyl)pentaphosphate + H(2)O = adenosine 5′-tetraphosphate + Amp. |
