dichloroarcyriaflavin A synthase EC#: 1.13.12.17; ChemWhat Code: 1375051
Product Name
dichloroarcyriaflavin A synthase
Example Structure
Synonyms
CYP245A1, cytochrome P450 StaP, P450 StaP, StaP
EC Number
1.13.12.17
CAS Registry Number
Comments
The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold [1]. Along with RebC, a flavin-dependent hydroxylase, it also catalyses the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A [2]. The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine [3].
