dichlorochromopyrrolate synthase EC#: 1.21.98.2; ChemWhat Code: 1376094
| Product Name | dichlorochromopyrrolate synthase |
| Example Structure |  |
| Synonyms | RebD |
| EC Number | 1.21.98.2 |
| CAS Registry Number | |
| Comments | This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin [1]. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center [2]. In vivo the enzyme uses hydrogen peroxide, formed by the enzyme upstream in the biosynthetic pathway (EC 1.4.3.23, 7-chloro-L-tryptophan oxidase) as the electron acceptor. However, the enzyme is also able to catalyse the reaction using molecular oxygen [3]. |
| Cofactor | heme b;Fe cation |
| History | |
| Reactions | 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H(2)O(2) = dichlorochromopyrrolate + NH(3) + 2 H(2)O. |
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