dihydrolipoyllysine-residue (2-methylpropanoyl)transferase EC#: 2.3.1.168; ChemWhat Code: 1376965
| Product Name | dihydrolipoyllysine-residue (2-methylpropanoyl)transferase |
| Example Structure |  |
| Synonyms | dihydrolipoyl transacetylase, E2, E2p, More |
| EC Number | 2.3.1.168 |
| CAS Registry Number | |
| Comments | A multimer (24-mer) of this enzyme forms the core of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively 2-methylpropanoylated by EC 1.2.4.4, and the only observed direction catalysed by EC 2.3.1.168 is that where this 2-methylpropanoyl is passed to coenzyme A. In addition to the 2-methylpropanoyl group, formed when EC 1.2.4.4 acts on the oxoacid that corresponds with valine, this enzyme also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated to it when EC 1.2.4.4 acts on the oxo acids corresponding with leucine and isoleucine. |
| Cofactor | |
| History | |
| Reactions | 2-methylpropanoyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-(2-methylpropanoyl)dihydrolipoyl)lysine. |
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