dihydrolipoyllysine-residue succinyltransferase EC#: 2.3.1.61; ChemWhat Code: 1376827
| Product Name | dihydrolipoyllysine-residue succinyltransferase |
| Example Structure |  |
| Synonyms | AceF, dihydrolipoamide succinyltransferase, dihydrolipoic transsuccinylase, dihydrolipolyl transsuccinylase, dihydrolipoyl succinyl transferase, dihydrolipoyl succinyltransferase, dihydrolipoyl transsuccinylase, DLST, E2 component of alpha-ketoglutarate dehydrogenase complex, lipoate succinyltransferase, lipoic transsuccinylase, lipoyl transsuccinylase, OGDC-E2, succinyl-CoA:dihydrolipoate S-succinyltransferase |
| EC Number | 2.3.1.61 |
| CAS Registry Number | 9032-28-4 |
| Comments | A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A. |
| Cofactor | |
| History | |
| Reactions | Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)- (S-succinyldihydrolipoyl)lysine. |
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